Microfracture technique in combination with intraarticular hyaluronic acid injection in articular cartilage defect regeneration in rabbit model.
نویسندگان
چکیده
Although articular hyaline cartilage typically has low potential for regeneration, numerous methods and techniques have been proposed to induce the reparation process. In our work, we used microfracture techniques in combination with intraarticular application of hyaluronic acid in rabbit knee articular cartilage defect. In comparison with the control group, after 6 and 10 weeks we observed a higher potential of healing in the experimental group, with thicker and more organized repair tissue filling the defect. In conclusion, a combination of the microfracture technique and application of hyaluronic acid might be potentially beneficial in inducing articular cartilage defect reparation.
منابع مشابه
Hyaluronic Acid Improves Repair Cartilage After Microfracture in Just 3 Once-Weekly Injections The Efficacy of Intra-Articular Hyaluronan Injection After the Microfracture Technique for the Treatment of Articular Cartilage Lesions
Objective: To measure the value of intra-articular viscosupplementation in the treatment of chondral injuries with microfracture. Design: Controlled laboratory study. Methods: In 36 New Zealand white rabbits, a 3-mm full-thickness chondral lesion was created in the weightbearing surface of the medial femoral condyle. A microfracture of the same lesion was then done. At 1 week, the 36 rabbits we...
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INTRODUCTION Microfracture does not properly repair full-thickness cartilage defects. The purpose of this study was to evaluate the effect of intraarticular injection of the small-molecule compound kartogenin (KGN) on the restoration of a full-thickness cartilage defect treated with microfracture in a rabbit model. METHODS Full-thickness cartilage defects (3.5 mm in diameter and 3 mm in depth...
متن کاملIntraarticular Hyaluronic Acid Injection after Microfracture Technique for the Management of Full-Thickness Cartilage Defects Does Not Improve the Quality of Repair Tissue
OBJECTIVE Tissue repair that occurs after microfracture does not include hyaline-like cartilage. Therefore, other treatment modalities must be combined with microfracture to improve repair tissue quality. In this study, we combined exogenous hyaluronic acid with microfracture. DESIGN Thirty mature New Zealand rabbits were randomly divided into 3 groups as control, microfracture (MF), and micr...
متن کاملArticular Cartilage Regeneration with Stem Cells
Cartilage defects continue to be a clinical challenge as regards to articular cartilage regeneration. The structure and function of articular cartilage leads to non-healing lesions after injury occurs. Well-established arthroscopic methods utilize controlled healing with marrow stimulation or transferring of non-injured cartilage to areas of injury. These include: microfracture, chondral drilli...
متن کاملThe efficacy of intra-articular hyaluronan injection after the microfracture technique for the treatment of articular cartilage lesions.
BACKGROUND Although the exact mechanism of action has yet to be elucidated, recent animal studies have demonstrated chondroprotective and anti-inflammatory properties of hyaluronic acid viscosupplementation. HYPOTHESIS Intra-articular hyaluronic acid after microfracture improves the quality of the repair leading to a more hyaline-like repair tissue with better defect fill and adjacent area in...
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ورودعنوان ژورنال:
- Collegium antropologicum
دوره 33 2 شماره
صفحات -
تاریخ انتشار 2009